Summary. Drug interactions are reported among people who take Protonix and Melatonin together. This study is created by eHealthMe based on reports of 563 people who take Protonix and Melatonin from FDA, and is updated regularly. Melatonin is a hormone naturally produced in the brain that helps regulate other hormones and aids in setting the body's circadian rhythm, or internal clock. DATE: 8.05.2012 AUTHOR: crisamcon Can you take melatonin along with protonix. Protonix and Synthroid Drug Interactions - Drugs.com View drug interactions between Protonix and Synthroid. These medicines may also interact with certain foods or diseases. Can you mix NyQuil with melatonin - The Q&A wiki Can you mix NyQuil with. Melatonin is used in many countries to improve sleep disorders. Melatonin is a hormone produced by the pineal gland and enterochromaffin cells which control sleep and gastrointestinal motility. Uses: Protonix is prescribed for GERD and Reflux and is mostly mentioned together with these indications. In addition, our data suggest that it is taken for Heartburn, although it is not approved for this condition*. A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. There is no known interaction between Melatonin and Pantoprazole in our records. However, an interaction may still exist. However, an interaction may still exist. Always consult your doctor before taking these medications together. I have gerd and anxiety and my throat is tight probably from both and I took a protonix about an 3 hours ago and I want to take a melatonin to relax and maybe my throat will too..is it safe to mix these? [return to home page: ] Melatonin and GERD. Jacob Schor ND FABNO. December 27, 2008. Since late spring 2006, five articles have been published in peer reviewed medical journals suggesting a relationship between the hormone melatonin and gastroesophageal reflux disease (GERD). Pros & Cons of PPIs: Proton pump inhibitors (PPIs) such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec) and pantoprazole (Protonix) are commonly prescribed to treat acid reflux.